ProtocolPulse

MRI Brain — Outpatient

MRI
NICE NG217 (Epilepsy)NICE NG220 (MS)NICE NG97 (Dementia)NICE NG99 (Brain Tumours)NICE CG150 (Headache)NICE NG128 (TIA)v2.0 · March 2026
Varies
Outpatient
All imaging requests must be justified by an IR(ME)R practitioner (radiologist or radiographer)

Epilepsy (NG217 Rec 1.3.1)

Offer MRI to ALL diagnosed epilepsy patients, with exceptions for idiopathic generalised epilepsy and self-limited epilepsy with centrotemporal spikes

  • Offer MRI to ALL diagnosed epilepsy patientsNICE NG217 Rec 1.3.1
  • Exceptions: idiopathic generalised epilepsy; self-limited epilepsy with centrotemporal spikes
  • CT only if MRI contraindicatedNICE NG217 Rec 1.3.2
  • Reports by neuroradiologistNICE NG217 Rec 1.3.4

Multiple sclerosis (NG220 Rec 1.1.3)

— ALL of the following must be met

  • MRI essential for diagnosis using 2017 McDonald criteriaNICE NG220 Rec 1.1.3
  • Dissemination in space and time on MRI
  • 2024 update: optic nerve added as fifth anatomical location

TIA (NG128 Recs 1.2.1–1.2.2)

Do NOT offer CT brain for suspected TIA; consider MRI with DWI and blood-sensitive sequences same day as specialist assessment

  • Do NOT offer CT brain for suspected TIANICE NG128 Rec 1.2.1
  • Consider MRI with DWI and blood-sensitive sequences same day as specialist assessmentNICE NG128 Rec 1.2.2

Brain tumour (NG12 Rec 1.9.1; NG99)

— ANY of the following

  • Urgent MRI (or CT if MRI contraindicated) within 2 weeks for progressive sub-acute loss of central neurological functionNICE NG12 Rec 1.9.1
  • MRI preferred over CT
  • Consider advanced MRI (perfusion, spectroscopy) for high-grade transformation

Dementia (NG97 Rec 1.2.12)

— ANY of the following

  • Structural imaging (CT or MRI) to rule out reversible causesNICE NG97 Rec 1.2.12
  • MRI preferred when vascular dementia suspected

Headache — NOTE ONLY (when NOT indicated)

Do NOT refer for neuroimaging for tension-type, migraine, cluster, or medication-overuse headache. Imaging IS indicated for red flags.

  • Do NOT refer for neuroimaging for: tension-type, migraine, cluster, medication-overuse headacheNICE CG150
  • Imaging IS indicated for red flags: thunderclap, new deficit, altered consciousness, positional, progressive

Pituitary

— ANY of the following

  • MRI with dedicated pituitary protocol

Notes

Warning

Do NOT routinely image headache without red flags

NICE CG150
Information

MRI epilepsy reports must be by neuroradiologist

NICE NG217
Information

ABCD2 no longer recommended for TIA

NICE NG128
Local preference

MRI preferred over CT for all outpatient brain indications

Pregnancy

MRI brain can be performed in pregnancy if clinically indicated. Gadolinium is contraindicated except when essential.

Modality Preference

MRI preferred. Superior soft tissue contrast; no ionising radiation; preferred for all listed outpatient indications

Source: NG217; NG220; NG97; NG99; CG150

Change Log

v2.02026-03-08New protocol — outpatient MRI brain indications consolidated

Not clinical advice. This protocol is a reference tool only. All imaging justifications remain the clinical and legal responsibility of the authorising practitioner under IR(ME)R 2017 (as amended 2024). Protocol content should be verified against current NICE, RCR, and specialty guidelines before use in practice.

AI-assisted content. Clinical criteria were developed with AI assistance and cross-referenced against cited source guidelines. Verify against original sources. Guidelines referenced are current at the stated version date and may have been updated since.